Synthesis of Potential Antimicrobial/Antitubercular s-Triazine Scaffolds Endowed with Quinoline and Quinazoline Heterocycles

Two series of 2–(4–cyanophenyl amino)–4–quinoline (quinazoline)–4–yloxy–6–piperazinyl (piperidinyl)–1,3,5–triazines were synthesized so as to investigate their antimicrobial and antitubercular action. Newer analogues were characterized by IR, 1H NMR spectroscopy and elemental analyses. Pharmacological screening against eight bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, S. flexneria), four fungi (A. niger, A. fumigatus, A. clavatus, C. albicans) and Mycobacterium tuberculosis H37Rv was examined and the effects of various substituents on biological profiles (MIC, 6.25-50 µg/mL) of final analogues were investigated. Some of the final analogues displayed good antimycobacterial activity (MIC, 12.5 µg/mL).