Clinical analysis of the onset characteristics and inducing factors of atypical renal tuberculosis

Objectives To investigate the characteristics and inducing factors of atypical renal tuberculosis, and to improve the diagnosis of atypical renal tuberculosis. Methods and materials We collected medical records and observed the pathological sections of renal tissue performed after nephrectomy from 217 patients diagnosed with renal tuberculosis using Mycobacterium tuberculosis culture, or/and Mycobacterium tuberculosis DNA (TB-DNA) testing using FQ-PCR(Fluorescent Quantitative Polymerase Chain Reaction), or/and postoperative pathology in the urology department of Hebei Chest Hospital from March 25, 2013 to February 6, 2024. Based on their onset characteristics, we divided them into the typical group (145 cases) and the atypical group (72 cases), and analyzed the chief symptoms and characteristics. Logistic regression was used to analyze the relevant factors, and the differences were compared in pathological changes of kidney, ureter, and bladder tissues after surgery, to explore the mechanism leading to atypical symptoms of renal tuberculosis. Results ①In the typical group (66.82%), bladder irritation is the main clinical manifestation. In the atypical group (33.18%), there are no obvious symptoms of bladder irritation. The primary manifestations include localized pain, kidney discomfort, and secondary systemic or local disease signs.Additionally, the incidence rate among women in the atypical group is higher than in the typical group (p Conclusions ①Atypical renal tuberculosis is an important part of renal tuberculosis. Its onset of symptoms is insidious and atypical, without obvious bladder irritation symptoms, which should cause high vigilance and attention.②Uncomplicated bladder tuberculosis is the direct cause of the absence of bladder irritation symptoms in atypical renal tuberculosis, and reduced humoral immune function, and tubercular virulence may be the relevant factors inducing the onset of atypical symptoms in renal tuberculosis. Clinical trial Not applicable.