Characterization of Mycobacterium Tuberculosis (MTB)-Positive Individuals within the Healthcare Catchment Area of Mzuzu Central Hospital, Malawi

Purpose To investigate the characteristics of the Mycobacterium tuberculosis (MTB)-positive population within the healthcare service area of Mzuzu Central Hospital in Malawi, with the objective of providing a scientific foundation for tuberculosis (TB) prevention and control strategies in the region. Methods This retrospective study encompassed 4,711 patients who underwent GeneXpert (GeneXpert MTB/RIF or GeneXpert MTB/RIF Ultra) testing. Data on laboratory results, demographics, HIV status, and residential addresses were analyzed. Results Among 4,711 patients, 424 (9%) tested MTB-positive. A strong correlation was observed between MTB and HIV infection, as HIV/TB co-infection accounted for 47.9% of MTB-positive cases (χ 2 =46.311, p 2 =66.858, p Conclusion Within the healthcare catchment area of Mzuzu Central Hospital, MTB infection is significantly associated with HIV. Males show a higher MTB positivity rate than females. The study identifies high-risk age groups, temporal trends, and geographical TB patterns. Rifampicin resistance is a critical issue needing urgent attention.