Advances in the mechanisms of drug resistance of Mycobacteriumtuberculosis

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has developed different mechanism of action against antimicrobial drug therapies, posing a significant threat to effective treatment against Mtb. This review article provides an overview of the recent advancements in the mechanism of drug resistance in Mtb and highlights how drugs target specific cellular processes. Additionally, we also discuss the intrinsic resistance mechanisms employed by Mtb and how alterations in drug target sites contribute to treatment failure.