Global research agenda for antimicrobial resistance in human health

This WHO publication presents a global research agenda for antimicrobial resistance (AMR) in human health, developed to identify and prioritize research areas with the greatest potential to reduce the impact of AMR. Recognizing AMR as a major global public health threat, the document addresses bacterial, fungal and drug-resistant tuberculosis pathogens of priority concern and highlights the disproportionate burden borne by low- and middle-income countries. The agenda is intended to guide policy-makers, researchers, funding agencies, implementing partners, industry and civil society in generating evidence to support effective AMR policies and interventions.

The agenda was developed through an adapted Child Health and Nutrition Research Initiative methodology involving a multidisciplinary international expert group. A systematic review of published and grey literature identified knowledge gaps, which were consolidated and prioritized through expert consultation and scoring against predefined criteria, including public health impact, feasibility, policy relevance and equity. The resulting 40 research priorities cover prevention, diagnosis, treatment and care, drug-resistant tuberculosis, and cross-cutting issues such as surveillance, antimicrobial stewardship, behavioural interventions, health systems, regulation and access. The document also outlines considerations for implementation, monitoring and evaluation, with the aim of promoting research investment and evidence generation through 2030 to support global efforts to mitigate AMR.