Outcomes and consequences of COVID-19 in comorbidity of tuberculosis and opportunistic respiratory infections in the late stages of HIV infection with immunodeficiency

The outcomes and consequences of COVID-19 in comorbidity of tuberculosis, opportunistic respiratory infections in 28 patients with stage IVB HIV infection, in the progressive phase and in the absence of ART c were studied in comparison with 28 similar patients without COVID-19. It was found that this comorbidity is characterized by severe immunodeficiency and generalization of tuberculosis with multiple extrapulmonary lesions. This determines the similarity of clinical manifestations and visualization of CT changes in this comorbidity, which makes it difficult to distinguish them due to the simultaneous layering of several pathologies with the same type of clinical and computed tomographic manifestations. After 1 year of follow-up, no clinical cure was established in all patients. Progression and death are associated with a lack of adherence to treatment, drug addiction, severe and generalized tuberculosis, and the development of opportunistic respiratory infections. Special microbiological and molecular genetic studies of diagnostic material from the respiratory system and other organs are needed to prescribe timely comprehensive treatment and reduce the mortality of this severe contingent of patients.