Domain architecture of the Mycobacterium tuberculosis MabR (Rv2242), a member of the PucR transcription factor family
Véronique Mégalizzi, Abdalkarim Tanina, Camille Grosse, Manon Mirgaux, Pierre Legrand, Gaëtan Dias Mirandela, Alexandre Wohlkönig, Pablo Bifani, et al. (9 authors)
Heliyon · 2024-11
Abstract
. Biochemical and computational studies suggest that full-length MabR forms both dimeric and tetrameric assemblies in solution. Structural analysis revealed two distinct dimerization interfaces within the N- and C-terminal domains, further supporting a tetrameric organization. These findings provide valuable insights into the domain architecture, oligomeric state, and potential regulatory mechanisms of MabR.
MeSH terms
- Domain (mathematical analysis)
- Mycobacterium tuberculosis
- Transcription factor
- Tuberculosis
- Medicine
- Microbiology