A Multidimensional Analysis of Factors Influencing Depression and Anxiety among Multidrug-Resistant Tuberculosis Patients

This study investigates multidimensional factors influencing depression and anxiety symptoms in multidrug-resistant tuberculosis (MDR-TB) patients, aiming to inform effective mental health intervention strategies. A cross-sectional study included 103 MDR-TB patients treated at our hospital from January 2021 to August 2024. Assessments utilized the Hospital Anxiety and Depression Scale (HADS), Connor-Davidson Resilience Scale (CD-RISC-10), and Perceived Social Support from Family Scale (PSS-Fa). Demographic and clinical data were collected. Statistical analyses (descriptive, correlation, multiple regression) were performed using SPSS 26.0. Depression and anxiety prevalence rates were 50.5% and 35.0%, respectively. Significant correlations linked depressive/anxious states with gender, activity levels, sleep quality, treatment stage, disease perception, healthcare experiences, family support, and resilience. Treatment stage, family support, and resilience emerged as key depression factors; gender, sleep quality, disease perception, family support, and resilience influenced anxiety. MDR-TB patients experience high depression and anxiety rates influenced by complex personal and environmental factors. Enhanced mental health education, personalized psychological support, optimized family involvement, and resilience training are crucial in clinical care to enhance mental health and treatment outcomes.