Variability of macrolide-resistant profile in <i>Mycobacterium avium</i> complex pulmonary disease
Kiyoharu Fukushima, Yuki Matsumoto, Yuko Abe, Kazuki Hashimoto, Daisuke Motooka, Seigo Kitada, Haruko Saito, Sho Komukai, et al. (23 authors)
Antimicrobial Agents and Chemotherapy · 2024-10
Abstract
ABSTRACT This single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with Mycobacterium avium complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).
MeSH terms
- Mycobacterium avium complex
- Macrolide Antibiotics
- Microbiology
- Mycobacterium avium-intracellulare infection
- Pulmonary disease
- Pulmonary infection
- Nontuberculous mycobacteria
- Medicine
- Mycobacterium
- Biology
- Internal medicine