Drug-induced liver injury in HIV-infected patients with active tuberculosis

High prevalence, variability of clinical manifestations, limited knowledge about mechanisms of toxicity, and difficulty in diagnosis make drug-induced liver injury one of the unsolved problems in clinical medicine. Drug-induced liver injury during antiretroviral and antituberculosis therapy is a serious complication, which can reach a severe degree, leading to acute liver failure. Studies to identify the frequency, type, and severity of drug-induced liver injury in HIV-infected patients with active tuberculosis are essential. The article summarizes the current data of scientific publications on the frequency, type, and severity of drug-induced liver injury in patients treated with antiretroviral and antituberculosis drugs. A search and subsequent analysis of scientific publications in MedLine, the Cochrane Library, PubMed, and Scopus was performed. Available data indicate a high incidence of drug-induced liver injury and variation in types and severity among TB/HIV patients. This necessitates the need to examine patients taking ART and anti-TB drugs for the occurrence of liver damage, especially those with high-risk conditions such as viral hepatitis and alcohol use. It should remain a key component of TB/ HIV treatment.