Complete Blood Count Indices as inflammatory Markers in Diabetic Patients with Active Pulmonary Tuberculosis

Background:The role of hematological indices in follow-up of pulmonary tuberculosis (PTB) has not been extensively investigated. Objectives: To evaluate the role of hematological indices as inflammatory markers in PTB course in (DM) and (NDM) patients. Methodology: prospective cohort study included 30 uncontrolled (DM-TB), 30 controlled (DM-TB), and 30 (NDM-TB) patients. All have active smear-positive PTB. The following parameters were reported before starting anti-TB treatment (baseline),and at 1st, and2nd months after starting treatment; (MCV), (RDW), (MCH), (MCHC), (MPV), (PDW), (NLR), (MLR) and (PLR). Results:MCV and RDW were significantly higher in uncontrolled DM-TB group than in the other two groups,and in the controlled DM-TB group than in the NDM-TB group at baseline,1st and2nd months. The RDW was significantly decreased from baseline till 2nd month in the uncontrolled and controlled DM-TB groups. The MPV was significantly lower in uncontrolled DM-TB group than in the other two groups, and in controlled DM-TB group than in the NDM-TB group at baseline, 1st and 2nd months. PDW was significantly reduced in uncontrolled and controlled DM-TB groups than in the NDM-TB group at 2nd month. In the uncontrolled and controlled DM-TB groups, the MPV and PDW were significantly increased during follow-up. The NLR and PLR were significantly higher in uncontrolled DM-TB group than the other two groups and in controlled DM-TB group than in NDM-TB group at 1st month. MLR was significantly higher in uncontrolled DM-TB group than in the other two groups and in controlled DM-TB group than in NDM-TB group at 1st and 2nd months. In uncontrolled DM-TB and controlled DM-TB groups the NLR, PLR, and MLR were decreased during follow-up. Conclusion:The MCV, RDW, MPV, PDW, NLR, PLR and MLR could have an important role in follow-up of PTB in diabetic patients and in predicting treatment outcome. Keywords: Complete blood count indices; tuberculosis; diabetes mellitus