Fluorinated trehalose analogues for cell surface engineering and imaging of <i>Mycobacterium tuberculosis</i>
Collette S. Guy, James A. Gott, Jonathan Ramírez-Cárdenas, Christopher de Wolf, Christopher M. Furze, Geoff West, Juan C. Muñoz–García, Jesús Angulo, et al. (9 authors)
Chemical Science · 2024-01
Abstract
The mycobacterial trehalose LpqY-SugABC ATP-binding cassette (ABC) transporter was hijacked to import fluorine-modified trehalose analogues to label cell-surface glycolipids and directly visualise the Mycobacterium tuberculosis pathogen by Focused Ion Beam (FIB) Secondary Ion Mass Spectrometry.
MeSH terms
- Trehalose
- Mycobacterium tuberculosis
- Glycolipid
- Chemistry
- Pathogen
- Cell
- Mass spectrometry
- Microbiology
- Biochemistry
- Tuberculosis