Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies
Teun van der Klugt, Robin H. G. A. van den Biggelaar, Anno Saris
Critical Reviews in Microbiology · 2024-06
Abstract
, this review provides a state-of-the-art overview of mycobacterial lipid metabolism and concomitant role of host metabolism and host-pathogen interaction therein. While doing so, we will emphasize unexploited bacteria-directed and host-directed drug targets, and highlight potential synergistic drug combinations that hold promise for the development of new therapeutic interventions.
MeSH terms
- Pathogen
- Mycobacterium tuberculosis
- Biology
- Tuberculosis
- Virulence
- Lipid metabolism
- Microbiology
- Immune system
- Antibiotics
- Antimicrobial
- Host (biology)
- Lipid A
- Bacteria
- Virology
- Immunology