VARIATION PROFILE OF SERUM CALCIUM IN PATIENTS SUFFERING FROM PULMONARY TUBERCULOSIS

Background Pulmonary Tuberculosis is a serious global health issue that has a significant influence on public health systems all over the world. Aims and Objectives: This study investigates the variation profile in serum calcium alterations associated with pulmonary tuberculosis (TB) caused by Mycobacterium in a Pakistani population. Study carried in Institute of Biochemistry University of Sindh Jamshoro in collaboration with Chest Centre disease Kotri, Indus hospital and Civil Hospitals respectively, samples were collected from Pulmonology wards of respective hospitals, from December 2022 to June 2023. Methods A retrospective case control study comprises total 200 participants, randomly selected 100 subjects of pulmonary tuberculosis and 100 age and gender matched healthy non T.B controls were analyzed for demographic characteristics of the patients and determination of calcium profile in PTB patients. Statistical analysis was done on SPSS software.  Results The detailed analysis of serum Calcium with Pulmonary Tuberculosis presents as calcium level mean ± SD 8.95 + 0.77 than in controls mean ± SD 9.49 + 0.81, with a p-value of 0.000, showing results are statically significant. Conclusion we have observed altered biochemical abnormalities such as hypocalcaemia, serum calcium levels were observed significantly low in TB patients as compare to healthy controls. This study may contribute to the development of improved diagnostic and monitoring tools for TB patients, facilitating early detection and effective disease management.