TB Research

[Progress in PD-1/PD-L1, PD-L2 signaling pathway and its role in host anti-tuberculosis immunity].

Xinjian Yu, Jie Zhang, Jianping Xie

PubMed · 2024-05

Abstract

infection. In this study, we reviewed that the regulatory roles of PD-1/PD-L1, PD-L2 signaling in the host adaptive immune response, such as the innate response of macrophages, and the interaction between T cells and macrophages in response to MTB. In addition, during MTB infection, PD-1/PD-L1, PD-L2 signaling is also involved in the host inflammatory response, as well as the potential roles of PD-1/PD-L1, PD-L2 in the diagnosis and treatment of tuberculosis.

MeSH terms

  • Immunity
  • Tuberculosis
  • Host (biology)
  • PD-L1
  • Palladium
  • Immune system
  • Immunology
  • Biology