[Research progress on the effect of Mycobacterium tuberculosis heat-resistant antigen (MTB-HAg) on γδ T cells].

Mycobacterium tuberculosis heat resistant antigen (MTB-HAg) is a polypeptide antigen released from Mycobacterium tuberculosis (MTB) H37Ra to the supernatant after being autoclaved at 121 DegreesCelsius for 20 minutes. γδ T cells are unconventional T cells widely distributed in non-lymphoid tissues. They secrete cytokines such as TNF-α and IFN-γ, and play an important role in the immune response against MTB infection. MTB-HAg can effectively stimulate the proliferation and activation of γδ T cells in vitro, enabling them to participate more efficiently in the anti-TB infection process. Therefore, MTB-HAg is a potential target for the design of novel TB vaccines or drugs. However, due to its complex composition, it is still unknown which component of MTB-HAg stimulates the anti-MTB infection function of γδ T cells.