Activity against <i>Mycobacterium tuberculosis</i> of a new class of spirooxindolopyrrolidine embedded chromanone hybrid heterocycles
Manal Fahad Alkaltham, Abdulrahman I. Almansour, Natarajan Arumugam, Siva Krishna Vagolu, Tone Tønjum, Shatha Ibrahim Alaqeel, R. Saiswaroop, Venketesh Sivaramakrishnan
RSC Advances · 2024-01
Abstract
Spirooxindolopyrrolidines were synthesized in quantitative yield through cycloaddition strategy. Compounds exhibited significant anti-tubercular activity and molecular docking studies of the compound is well correlates with in vitro findings.
MeSH terms
- Mycobacterium tuberculosis
- Class (philosophy)
- Tuberculosis
- Traditional medicine
- Chemistry
- Medicine