Prevalence of rifampicin resistance among tuberculous Patients In Khartoum State, Sudan

Background:Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Rifampicin resistance Tuberculosis (RR-TB) defined as resistance to rifampicin detected using genotypic or other first method with or without resistance to other first line anti-TB drugs, RR-TB is emerging as a major problem due to poor management of drug sensitive as well as drug resistance TB. Objectives:The study aimed to determine the prevalence of the drug resistant (rifampicin among TB patients) in Khartoum state.Materials and methods:This study was cross-sectional study performed on 75 Sudanese individuals; sputum samples were collected from 75 patients with tuberculosis; whose are sub divided according to their severity into mild patients and high patients. The Drug Resistant (Rifampicin) among T.B Patient’s detected by GeneXpert. The statistical analysis was conducted using SPSS 26 computer program.Results:This study was conducted among 75 Sudanese patients with tuberculosis as case group. Mean and SD of age was (30.6 ± 6.4 years) Age was grouped to four age group; the most common age group was between 21-30 years. And found that two patients had resistant strain of M. Tuberculosis.Conclusion: The study was concluded Gene Xpert MTB/RIF is useful tool for detection of TB and RIF resistance on primary respiratory specimens. And found that two patients had resistant strain of M.tuberculosis.