Epidemiology of Latent Tuberculosis in Moroccan Healthcare Workers: Prevalence Patterns and Predisposing Factors

Background Among occupational hazards in healthcare settings, latent tuberculosis infection (LTBI) ranks as a major concern, particularly threatening healthcare workers (HCWs) in nations grappling with intermediate to high tuberculosis (TB) rates. Our study was conducted in Morocco, a country characterized by widespread Bacillus Calmette-Guérin (BCG) vaccination and a moderate TB burden of 93 cases per 100,000 inhabitants in 2022. We examined both the prevalence of LTBI among Moroccan HCWs and its various risk factors. Methods A cross-sectional study was conducted from August 2022 to October 2024 in two Moroccan hospitals. One hundred forty-seven HCWs were recruited and screened for LTBI using the QuantiFERON-TB Gold In-Tube (QFT-GIT) test. Data on demographics, occupational characteristics, and potential risk factors were collected through standardized questionnaires. Statistical analysis included univariate and multivariate logistic regression to identify factors associated with LTBI. Results The overall prevalence of LTBI was 32.65% (48/147). Multivariate analysis identified several independent risk factors: male gender (OR: 2.84; 95% CI: 1.54-5.22; p Conclusions The observed LTBI prevalence among HCWs in Morocco demonstrates concordance with epidemiological data from comparable intermediate-burden nations. The elucidation of predisposing factors, with particular emphasis on non-occupational determinants, underscores the imperative for implementing systematic surveillance protocols and World Health Organization (WHO)-sanctioned infection prevention measures within healthcare facilities. These epidemiological findings provide an empirical foundation for the formulation and optimization of TB control strategies specifically tailored to the occupational health needs of Morocco's healthcare workforce.