Exploration of triazole derivatives, SAR profiles, and clinical pipeline against Mycobacterium tuberculosis

Tuberculosis is a highly infectious disease and it is a global threat in particular affecting people from developing countries. It is thought that nearly one-third of the global population lives with this causative bacterium in its dominant form. The spread of HIV and the development of resistance to both multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) aggravates the spread of the disease and needs novel drugs which combat this disease effectively. Triazole-containing anti-tubercular drugs are promising and need further tuning to develop as a potent scaffold for tuberculosis. In this review, we highlight the structural activity relationships of triazole-containing drugs and detailed understanding for the researchers in the field of medicinal chemistry to further explore these triazole-based compounds as well as synthesize new compounds for antitubercular activity against drug-sensitive and resistant strains.