Clinical Significance of Hyponatremia in Tuberculous Meningitis: A Prospective Cohort in Indonesia

Background Hyponatremia is common in tuberculous meningitis (TBM), but its impact on disease severity and outcomes is unclear. Methods In a cohort of 864 adult patients with TBM in Indonesia, we assessed the prevalence and prognostic significance of hyponatremia, classified as moderate (120-130 mEq/L) or severe ( Results Hyponatremia occured in 86.8% of patients, with 26% classified as severe. Severe hyponatremia associated with male, younger age, a lower Glasgow Coma Scale (GCS), and markers of more severe disease ( P Conclusions Hyponatremia reflects disease severity in TBM but does not independently predict mortality, suggesting limited benefit from agressive correction.