The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against <i>Mycobacterium tuberculosis</i>
Komarova K, Vinogradova L, Lukin A, Zhuravlev M, Deniskin D, Chudinov M, Gureev M, Dogonadze M, et al. (12 authors)
Molecules (Basel, Switzerland) · 2024-06
Abstract
A series of 21 new 7'H-spiro[azetidine-3,5'-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis . Two compounds had lower minimum inhibitory concentrations against Mtb (H37Rv strain) compared with isoniazid. The novel spirocyclic scaffold shows excellent properties for anti-tuberculosis drug development.
MeSH terms
- Mycobacterium tuberculosis
- Nitrofurans
- Azetidines
- Spiro Compounds
- Antitubercular Agents
- Microbial Sensitivity Tests
- Molecular Structure
- Structure-Activity Relationship