Bacteriological spectrum and drug susceptibility in post tuberculosis bronchiectasis

<b>Introduction:</b> Post TB lung disease remains the most common cause of bronchiectasis in developing nations causing progressive airway destruction, morbidity and reduced quality of life. Aims and Objective: To determine the bacteriological spectrum of organisms and their sensitivity pattern detected in patients of post-TB bronchiectasis and to help give empiric antibiotics to patients. Method: A descriptive cross-sectional study was conducted in the inpatient and outpatient departments of pulmonology OJHA Institute of Chest Disease, Dow University of Health Sciences, Karachi from 16-11-2020 to 15-05-2021. 135 diagnosed patients of post-Tb bronchiectasis were chosen by non-probability consecutive sampling technique with age between 18 - 60 years. Bronchiectasis was verified by performing HRCT chest. Sputum sample was gathered from each patient and analysed for culture for proof of microorganisms and drug susceptibility. <b>Results:</b> Total male patients were 51.9% and female patients were 48.1% with mean age of 43.4 ± 14.2 years. Isolated microorganisms in patients are listed below: Antibiotic resistance was highest with Penicillin (100%) followed by Co-trimoxazole (94.8%), Moxifloxacin (86%), Tetracycline (74.5%) and Erythromycin (60%) and highest sensitivity (100%) with Amikacin, Amoxicillin, Co-amoxiclav, Cefixime, Ceftazidime and Ceftriaxone. <b>Conclusion:</b> P. aeruginosa was the most commonly isolated microorganism in post-TB bronchiectasis being 100% sensitive with ceftazidime.