Clinical management of anti-tuberculosis related cutaneous adverse drug reactions based on reintroduction

The prevalence of anti-tuberculosis related adverse cutaneous reactions is around 1%. The most frequent reaction is exanthema, then urticaria and drug rash with eosinophilia and systemic symptoms (DRESS). Sequential drug reintroduction helped identifying rapidly the main culprit drug with good outcome. Rifampicin and pyrazinamide were the two most culprit drugs. DRESS was attributable to ethambutol and rifampicin.