Association of Cytochrome P450 2E1 and N-Acetyltransferase 2 Genotypes with Serum Isoniazid Level and Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Cross-Sectional Study.
Nasir Pourmohamadi, Mihan Pour Abdollah Toutkaboni, Nasim Hayati Roodbari, Payam Tabarsi, Shadi Baniasadi
PubMed · 2023-09
Abstract
Background: ) genes on serum isoniazid level and drug-induced hepatotoxicity. Methods: test. P<0.05 was considered statistically significant. Results: C1/C1 genotype was significantly associated with hepatotoxicity (P<0.001). Conclusion: genotypes and/or INH concentration can be a valuable tool to identify patients susceptible to hepatotoxicity.
MeSH terms
- Medicine
- Isoniazid
- Genotype
- Tuberculosis
- Gastroenterology
- Internal medicine
- CYP2E1
- Haplotype
- Pharmacology