PREVALENCE OF ANTI-PHOSPHATIDYLSERINE, ANTI-ANNEXIN AND ANTI-PROTHROMBIN ANTIBODIES IN PATIENTS WITH PULMONARY TUBERCULOSIS

INTRODUCTION– Tuberculosis is an infectious disease of complex interaction with the host, the understanding of this process can take major steps in knowledge towards diagnosis and treatment even more efficiently. The presence of antiphospholipid antibodies (aPL) has been shown on articles in various infections, as well as in tuberculosis and autoimmune disease, but the repercussions on patients is unclear. OBJECTIVE– This work studied the prevalence of three antibodies (antiphosphatidylserine, antiprothrombin and antiannexin V) in serum of fifty patients with lung tuberculosis in supervision at the service of infectology inSanta Izabel Hospital. METHODS– This is a descriptive study of cases series report. A sample of blood was collected from patients in supervision at the ambulatory service of the hospital from September 2009 to December 2009. The serum levels of the studied antibodies were determined and analyzed using descriptive statistics at the Excel 2016 software, determining its prevalence. RESULTS- Considering all fifty patients studied, thirteen (26%) had at least one antibody positive. The most prevalent antibody was antiprothrombin with 14%. Antiphosphatidylserine and antiannexin V respectively showed 6% and 8% of prevalence. Considering the sex, 20% of female patients had positive tests for antiprothrombin and 12% for antiphosphatidylserine, it wasn’t found positive tests to antiannexin V in the female population. In male sex the antibodies prevalence of antiprothrombin, antiphosphatidylserine and antiannexine was, respectively, 8%, 4% and 12%. LIMITATIONS OF THE STUDY AND CONCLUSION- The study presented limitations in order to investigate the clinical outcomes of the patients studied and it was not possible to access the epidemiological data of the patients. The objective to demonstrate the prevalence of antibodies was reached, but other studies are needed in light of the theme since that it was only possible to compare data of prevalence of only one antibody due to the lack of studies about the subject.