TB Research

Human T-cell Lymphotropic Virus Type-1-associated Bronchioloalveolar Disorder with Non-necrotizing Granulomas: A Case Report and Literature Review

Satomi Kimura, Yukihiro Umeda, Ryoko Egashira, Kazuhiro Tabata, Akifumi Muramoto, Mihoko Morita, Makiko Yamaguchi, Yuko Waseda, et al. (11 authors)

Internal Medicine · 2023-08

Abstract

Human T-cell lymphotropic virus type-1 (HTLV-1)-associated bronchioloalveolar disorder (HABA) is a pulmonary disorder characterized by lymphocytic infiltration of the peribronchiolar space and interstitium in HTLV-1 carriers and in adult T-cell leukemia/lymphoma (ATLL). We herein report an 85-year-old woman carrying HTLV-1 with HABA who presented with a miliary pattern of micronodules in both lungs on high-resolution computed tomography and a lymphocytic infiltrate with non-necrotizing granulomas on pathology. This rare case of HABA should be differentiated from sarcoidosis, hypersensitivity pneumonitis, or miliary tuberculosis.

MeSH terms

  • Pathology
  • Medicine
  • Miliary tuberculosis
  • Lymphoma
  • Sarcoidosis
  • Giant cell
  • Virus