Hepatoprotective activity of methanolic root extract Mahonia leschenaultii of in wistar rats

The ethanolic extract of Mahonia leschenaultii root was screened for hepatoprotective in hepatotoxic Albino rats induced via isoniazid and rifampicin. The degree of protection was measured by estimating biochemical parameters such as serum total protein, serum glutamate pyruvate transaminases (ALT/SGPT), serum glutamate oxaloacetate transaminases (AST/SGOT) and alkaline phosphatase (ALP). The ethanolic extract (100 mg/kg, 200mg/kg, 400mg/kg) exhibited significant hepatoprotection in isoniazid and rifampicin in toxicated rats in a dose dependant manner. The hepatoprotective effects of the extract were comparable with the standard drug silymarin 75mg/kg body weight, orally.