Acute Psychosis Secondary to Isoniazid in a Patient with Pulmonary Tuberculosis

Isoniazid (INH) is one of the first-line drugs used in the treatment of tuberculosis (TB).Though considered safe, mild to moderate adverse reactions secondary to INH has been noted in various patients.In some cases, though infrequent, INH may induce psychiatric reactions including delirium, hallucinations, paranoia, acute psychosis, etc., via acting as a monoamine oxidase (MAO) inhibitor or by decreasing pyridoxine.The present report details a case of acute psychosis secondary to INH use in a 47-year-old female patient with pulmonary tuberculosis.