TB Research

Targeted and efficient delivery of rifampicin to macrophages involved in non-tuberculous mycobacterial infection <i>via</i> mannosylated solid lipid nanoparticles

Jayoung Chae, Seung Hyun Kang, Jiwon Kim, Yonghyun Choi, Shin Hyuk Kang, Jonghoon Choi

Nanoscale Advances · 2023-01

Abstract

, a causative agent of non-tuberculous lung disease. Therefore, this study demonstrated that mannose receptor-targeted rifampicin delivery through solid lipid nanoparticles can be effectively applied to the treatment of non-tuberculous lung disease. Moreover, Man-RIF SLNs could also be used for the targeted delivery of drugs to several types of carcinoma cells or immune cells, as well as to treat lung diseases.

MeSH terms

  • Solid lipid nanoparticle
  • Rifampicin
  • Microbiology
  • Macrophage
  • Tuberculosis
  • Medicine
  • Drug delivery
  • Chemistry