SPECTRUM OF GRANULOMATOUS LESIONS IN A TERTIARY CARE HOSPITAL

Background and goals: Granulomatous inammation is being a manifestation of many infective, toxic, allergic, autoimmune, neoplastic diseases and also conditions of unknown etiology. The histological patterns in the various granulomatous diseases may be sufciently different to allow reasonably accurate diagnosis by experienced pathologist. The purpose of this study was to study etiology and histological pattern of granulomatous lesions in a tertiary care hospital. Materials and methods: The present study was retrospective and prospective observational study conducted in the Department of Pathology at Dr. V.M.G.M.C. Solapur. All incisional and excisional biopsies received from June 2017 to June 2022 showing granulomatous lesions were studied. Total 172 granulomatous lesions were evaluated histologically to know the possible etiology of granuloma. Wherever necessary special stains were carried out. In the present study, granulomatous l Observation and results: esions (24.4%) were most frequent in the age group of 21-30 years with mean age of the patient 38.5+15.71 years. The most common cause of granulomatous lesions was tuberculosis seen in 41 cases (23.8%) followed by foreign body 35 cases (20.3%), fungal infections 33 cases (19.2%), leprosy 17 cases (9.9%), neoplastic 5 cases (2.9%), actinomycosis and sarcoidosis 2 cases each (1.2%) and unknown origin in 36 cases (21%). The most common histological pattern of granuloma was epithelioid type seen in 65 cases (37.8%). M Conclusion: ajority of granulomatous lesions were infectious origin, in which tuberculosis is considered rstly in the differential diagnosis of granulomatous diseases, especially in the countries with a high incidence of tuberculosis. Histological pattern of granuloma can narrow the differential diagnosis. Histopathology remains gold standard for the diagnosis and management of variety of granulomatous lesions.