Author response: Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis
Pierre Dupuy, Shreya Ghosh, Allison Fay, Oyindamola Adefisayo, Richa Gupta, Stewart Shuman, Michael S. Glickman
Abstract
Genetic and biochemical analyses reveal an important role for the translesion DNA polymerase DinB2 in mycobacterial mutagenesis, including in the insertion/deletion events that are an increasingly recognized type of diversity in Mycobacterium tuberculosis genomes.
MeSH terms
- Mutagenesis
- Polymerase
- DNA polymerase
- Frameshift mutation
- Mycobacterium smegmatis
- Biology
- Genetics
- Mutation
- DNA repair
- DNA