FLASH-TB: an Application of Next-Generation CRISPR to Detect Drug Resistant Tuberculosis from Direct Sputum
Trinh Thi Bich Tram, Vu Thi Ngoc Ha, Le Pham Tien Trieu, Philip Ashton, Emily Crawford, Do Dang Anh Thu, Nguyen Le Quang, Guy Thwaites, et al. (11 authors)
Journal of Clinical Microbiology · 2023-04
Abstract
copies. Drug resistance predictions for 15/16 (93.7%) clinical samples were highly concordant with phenotypic DST for isoniazid, rifampicin, amikacin, and kanamycin [15/15 (100%)], ethambutol [12/15 (80%)] and moxifloxacin [14/15 (93.3%)]. These results highlighted the potential of FLASH-TB for detecting Mtb drug resistance from sputum samples.
MeSH terms
- Ethambutol
- Sputum
- Drug resistance
- Mycobacterium tuberculosis
- Tuberculosis
- Rifampicin
- Bedaquiline
- Moxifloxacin
- Extensively drug-resistant tuberculosis
- Isoniazid
- Virology
- Amikacin
- Capreomycin
- Biology
- Microbiology
- Kanamycin
- Medicine