Landscape of Exhausted T Cells in Tuberculosis Revealed by Single-Cell Sequencing
Jiahui Pan, Xinyue Zhang, Jianting Xu, Zecheng Chang, Zhuoyuan Xin, Guoqing Wang
Microbiology Spectrum · 2023-03
Abstract
Identifying the changes in immune cells in response to infection can provide a better understanding of the effects of Mycobacterium tuberculosis on the host immune system. We performed single-cell RNA-sequencing analysis of CD4 + T and CD8 + T cells isolated from peripheral blood mononuclear cells of healthy individuals and patients with tuberculosis to reveal the cellular characteristics.
MeSH terms
- Tuberculosis
- Mycobacterium tuberculosis
- CD8
- Biology
- Immune system
- Peripheral blood mononuclear cell
- Immunology
- Transcriptome
- T cell
- Cell
- Cytotoxic T cell
- Gene
- Virology