Editor's evaluation: Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I
Bavesh D Kana
Abstract
Human macrophages infected with Mycobacterium tuberculosis present peptides derived from substrates of type VII secretion systems on MHC class I via a pathway dependent on the ESX-1 secretion system and independent of antigen processing by the proteasome and cathepsins.
MeSH terms
- Antigen processing
- Major histocompatibility complex
- Antigen presentation
- Antigen
- MHC class I
- Mycobacterium tuberculosis
- Cross-presentation
- Biology
- Tuberculosis
- MHC class II
- Phagosome
- Computational biology
- Immunology
- T cell