Editor's evaluation: GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis
Digby F. Warner
Abstract
Genome sequence analysis of Mycobacterium tuberculosis clinical isolates and subsequent validation in laboratory and animal infection models identify previously unrecognized genetic mutations in DNA repair genes that contribute to the development of drug resistance.
MeSH terms
- Mycobacterium tuberculosis
- Genome-wide association study
- Drug resistance
- Computational biology
- Biology
- Tuberculosis
- Genetics