Short Lecture “Isoquinoline alkaloids and their derivatives as a new class of antimycobacterial drugs”

Tuberculosis (TB) is a widespread infectious disease caused by Mycobacterium tuberculosis (Mtb). According to the Global Tuberculosis Report 2021, issued by the World Health Organization (WHO), the latent form of Mtb has infected about a quarter of the worldʼs population, but only a small part (5 – 10%) will develop this bacterial disease [1]. The increasing incidence of multidrug-resistant (MDR), and extensively drug-resistant (XDR) strains has created a need for new antiTB agents with new chemical scaffolds to combat the disease. Thus, the key question is: how to search for new antiTB and where to look for them? One of the possibilities is to search among natural products.