Clinical outcome following lung transplantation in patients with CF colonized with Burkholderia cepacia complex: results from Mater Hospital lung transplant center Dublin.

<b>Background:</b> Burkholderia cepacia complex (BCC) is a gram negatuve bacterium causes serious opportunistic infections and has emerged as major pathogen in patients with CF, with the clinical outcome of infection varying from long term bronchial colonization of life threatening necrotizing penumonia and sepsis, known as "cepacia syndrome". Conflicting results have been published concerning post-transplantation outcome. <b>Methods:</b> A retrospective analysis was conducted of all patients with CF colonized with BCC underwent lung transplants in Mater Hospital from 2014-2020. <b>Results:</b> Four of the lung transplant patients with CF were infected with BCC (B cenocepacia(n=1), B multivorans (n=2) and B stabilis (n=1). ll the reported cases have persistence positive cultures (sputum/BAL) for BCC post lung trasplant to date. One reported case of capacia syndrome/sepsis developed in 24year old female patient post 2months post lung transplant. Treated with 12 weeks of systemic antibiotics accordning to the synergy testing with&nbsp;tigecycline, ceftazidime, fosfomycin and daptomycin. The same patient recently developed sternal wire infection and sternal abscess secondary to BCC positive culture developed 3 years pos the transplant. That was treated with surgical drainage of the abscess and wire removal. CLAD was not common among this group of patients. <b>Conclusion:</b> Infection with BCC preoperatively remains a challenging issue especially after using the common immunosupressive agents post lung trasplant with subsequent risk of sepsis.