The risk factors for tuberculosis in patients with psychic pathologies

Patients with psychic pathologies (PP) have an increased risk for tuberculosis (TB) and constitute a risk group for active screening in the Republic of Moldova (RM). The aim of the study was to identify the risk factors (RF) for&nbsp;TB in patients with PP and their treatment outcome. A&nbsp;selective, prospective and case-control study was conducted, which included 212 TB patients, distributed in a study group (SG) with 71 cases with PP registered during 2015-2019 and control group (CG)-141 without mental disorders/PP registered duing 2019 in RM.&nbsp;Multivariable logistic regression analysis estimated the odds ratio (OR) and 95% CI. <b>Results:</b> men OR=3,2 (CI 95%:3,1-9,3), urban residence OR=6,1(CI 95%:3,1-12,1), homelessnes OR=89,1(CI 95%:12-661), economic migration OR=14(CI 95%:9-113,4), unemployment OR=3,5(CI 95%:1,5-8,1), no health insurance OR=4,2(CI 95%:2,4-7,2), low education level OR=2,3(CI 95%:1,2-4,2), history of detention OR=19(CI 95%:2,4 - 148), TB contact OR=11(CI 95%: 7-110,4), TB/HIV coinfection OR=8(CI 95%:1,6-69). Outcomes in SG were: treatment success was registered in 37(52%) and died 20(28%) cases vs 107(76%) and 12(8%) patients in CG, respectively; failed/lost to follow-up were 14(20%) vs 22(16%)&nbsp;patients. <b>Conclusions:</b> RF of patients with PP are hard-to-reach characteristics, low social economical state, migration, history of detention, TB/HIV co-infection and TB contact. The PP and associated RF reduced the&nbsp;treatment effectiveness. Was obtained a low treatment success rate and high rate of deaths. Patients with PP and TB should receive an individualized approach according to the individuals needs.