Four months of rifampicin for tuberculosis prevention treatment in children

We have read with interest the systematic review by Santos et al. in the Journal of Infection and Chemotherapy [ [1] Santos J.M. Fachi M.M. Beraldi-Magalhães F. Böger B. Junker A.M. Domingos E.L. et al. Systematic review with network meta-analysis on the treatments for latent tuberculosis infection in children and adolescents. J Infect Chemother. 2022 Sep 6; 12 (PMID: 36075488, S1341-321X(22)00249-5, In this issue): 1645-1653https://doi.org/10.1016/j.jiac.2022.08.023 Abstract Full Text Full Text PDF Scopus (4) Google Scholar ]. We congratulate the authors for the choice of their subject. Children exposed to tuberculosis are at high risk for the disease and preventive tuberculosis treatment (TPT) of contact children is a high priority for the United Nations [ [2] United NationsPolitical Declaration of the UN General Assembly High-Level Meeting. https://www.who.int/tb/unhlmonTBDeclaration.pdf Google Scholar ] and the World Health Organization [ [3] WHOWHO consolidated guidelines on tuberculosis: module 1: prevention: tuberculosis preventive treatment. https://www.who.int/publications-detail-redirect/who-consolidated-guidelines-on-tuberculosis-module-1-prevention-tuberculosis-preventive-treatment Google Scholar ]. However, we are very concerned by the methods and conclusions of their systematic review.