Structural and Functional Annotation of Hypothetical Protein P9WIB9 of Mycobacterium tuberculosis H37Rv: An In-Silico Approach

The Mycobacterium tuberculosis (MTB) considered one of the most well-known, significant, and long-lasting infectious illnesses, tuberculosis (TB). MTB is becoming one of the main causes of mortality globally. In chorismate mutase, the protein P9WIB9 found in Mycobacterium Tuberculosis H37Rv has an important role. Chorismate mutase is required. The Claisen rearrangement of chorismate to prephenate for Catalyzes. It might have a role in pathogenicity. An in-silico technique for structural and functional documentation of the HP P9WIB9 was developed in this work. The expected tertiary structure was assessed using three servers: Modeller, Phyre2, and Swiss Model. Using structural analyses that consider data from the Ramachandran plot, Swiss-Model Workplace, verify 3D, ProSA-web and Z scores, the best materials are chosen. This investigation aimed to determine the function of the P9WIB9.1 protein produced by Mycobacterium tuberculosis H37Rv. As a result, this research will improve our understanding of pathophysiology and provide us the opportunity to selectively target the protein complex.