Nephroprotective Effect of Ethanol Extract of Carica Papaya Seed on Rats Induced Rifampicin and Isoniazid

Abstract Tuberculosis (TB) is an airborne, completely curable infection. The most common type is referred to as pulmonary TB. Rifampicin (RIF) is the first-line therapy for tuberculosis along with isoniazid (INH), ethambutol (ETB), and pyrazinamide (PZA). Papaya seeds are known to contain high concentrations of polyphenols, flavonoids, triterpenoids, tannins, saponins, alkaloids, glycosides, reducing sugars, steroids, proteins, lipids, anthraquinones, and anthocyanosides. The RIF is the most commonly prescribed anti-TB drug and most studies associate it with acute kidney injury. In this study, papaya seed ethanol extract was treated with different doses. For the test, eight groups of rats were used: normal, negative 1, negative 2, negative 3, positive, treatment I (100 mg/kg BW), treatment II (100 mg/kg BW), 300 mg/kg BW), and treatment III (500 mg/kg BW). After dissection of the mice, serum whey protein concentrations were measured. The results showed that compared to the negative control group, papaya seed ethanol extract significantly reduced urea, creatinine, uric acid, and creatinine clearance (<P0.05).