Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia
Mareli Claassens, Viola Dreyer, Emmanuel Nepolo, Q. Mokomele, Gerhard van Rooyen, Nunurai Ruswa, Gunar Günther, Stefan Niemann
Microbiology Spectrum · 2022-09
Abstract
The transmission of drug-resistant tuberculosis (TB) is a major problem for global TB control. Using genome sequencing, we showed that 13% of the multidrug-resistant (MDR) M. tuberculosis complex strains from Namibia are already pre-extensively drug resistant (pre-XDR), which is substantial in an African setting.
MeSH terms
- Tuberculosis
- Mycobacterium tuberculosis
- Mycobacterium tuberculosis complex
- Genome
- Transmission (telecommunications)
- Drug resistance
- Biology
- Whole genome sequencing
- Multiple drug resistance
- Genetics
- DNA sequencing
- Computational biology
- Virology