Ameliorative potential of Crataegus songarica against Isoniazid and Rifampicin Induced Hepatotoxicity in Albino Wistar Rats

Six rats for every five groups were selected randomly for this study. Ethanolic extract of Crataegus songarica and Liv-52 were given orally once daily for the time period of 28 days in Isoniazid and Rifampicin treated groups. Further, the level of serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin and total protein was evaluated followed by the histological examination of liver tissues. Results found considerably raised in almost all the tested parameters. Total bilirubin due to Isoniazid and Rifampicin treatment were ameliorated near to standard level in a concentration-dependent manner when the rats were given admittance to ethanolic extract of C.songarica. Meanwhile, the decreased level of total protein was also restored near to the normal level. The biochemical markers were fully augmented with histological examinations of the rat liver sections. The ethanolic extract of leaves of C.songarica showed potent hepatoprotective potential against Isoniazid and Rifampicin-induced hepatic damage in rats.