Association of Polymorphic Gene Variants of Xenobiotic Biotransformation Enzymes with Lung Tissue Destruction in Tuberculosis Patients

The objective: to investigate the association of polymorphic gene variants of xenobiotic biotransformation enzymes ( NAT2, CYP2E1, ABCB1, GSTM1, GSTT1 ) and cytokines ( IL1B, IL-4, IL-10, TNF ) with lung tissue destruction in pulmonary tuberculosis patients. Subjects and Methods . An ethnically homogeneous population sample of unrelated individuals of Slavic nationalities (mainly Russians) living in Kursk Oblast suffering from new pulmonary tuberculosis was examined. Results . New pulmonary tuberculosis with no destructive changes in the lungs was associated with the EE genotype of the GSTM1 gene ( p < 0.0001) in 89.5%, while the DD genotype of the GSTM1 gene ( p < 0.0001) was associated with the presence of destructive changes in the lungs in 56.1% of cases; the dominant GG genotype of the TNF-α gene was associated with destructive changes in the lungs in 93.3% ( p = 0.027), and the recessive GA genotype of the TNF-α gene was associated with no destructive changes in the lungs in 71.9% ( p = 0.027).