High clustering rate and genotypic drug-susceptibility screening for the newly recommended anti-tuberculosis drugs among global extensively drug-resistant <i>Mycobacterium tuberculosis</i> isolates
Kanwara Trisakul, Ditthawat Nonghanphithak, Pratchakan Chaiyachat, Orawee Kaewprasert, Kankanon Sakmongkoljit, Wipa Reechaipichitkul, Angkana Chaiprasert, David Blair, et al. (10 authors)
Emerging Microbes & Infections · 2022-07
Abstract
genes, conferring resistance to cycloserine, were found in 153/513 isolates (29.8%). No known mutations associated with linezolid resistance were detected. Cluster analysis showed that 408/513 isolates fell within 99 clusters and that 354 of these isolates were possible primary drug-resistant TB (292 XDR-TB, 57 pre-XDR-TB and 5 MDR-TB). Clonal transmission of primary XDR isolates might contribute significantly to the high prevalence of DR-TB globally.
MeSH terms
- Clofazimine
- Bedaquiline
- Drug resistance
- Tuberculosis
- Linezolid
- Mycobacterium tuberculosis
- Extensively drug-resistant tuberculosis
- Genotype
- Virology
- Biology
- Multiple drug resistance
- Microbiology
- Medicine