A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster.

Objectives: ) does not show enough protection in the vaccinated population. Materials and Methods: as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: to boost BCG efficiency.