Lung tuberculosis characteristics in association with herpesvirus infection

<b>Introduction:</b> Lung tuberculosis with multidrug resistance (MDR-TB) still is a global world problem. Human herpesviruses (HHV) is a widespread agents that can lead to asymptomatic illness condition and coinfection bacterial diseases progression. <b>Aim of the study:</b> Frequency estimation of HHV in lung tuberculosis patients with or especially without HIV-infection and its correlation to MDR-TB characteristics and disease progression. <b>Methods:</b> The results of case-control study performed. 233 patients with lung TB were examined, 144 (61,8%) — HIV-positive (C1-C3 stage,&nbsp;death rate 27,8%), 89 (38,2%) — HIV-negative (death rate 12,4%). Diagnosis of TB was made on the results of standard clinical and X-ray examination. Samples of blood were tested with immunoferment analysis to detect the quantitative rate of antibodies in serum for cytomegalovirus (CMV), HHV type I and II, virus Epstein-Barr (EBV), HHV antigens was detected as well. <b>Results:</b> Analysis of frequency rates of HHV in patients with lung tuberculosis without HIV showed that immune markers of active CMV was tested in 19.1%, HHV I — in 42.7%, EBV — in 27%, in HIV group it was 27,1% (p&lt;0,05), 54,7% (p&lt;0,1), 21,9% (p&lt;0,05) as well. The main indicator of activity was simultaneously hi levels of HHV antibodies IgM and IgG in samples of blood serum. Disseminated form of TB prevalence was shown in both groups. HHV activation was associated with MTB MDR and XDR in HIV patient. High mortality rate in patients with HHV activity markers showed. <b>Conclusions:</b> Frequency of HHV in patients with lung tuberculosis is simultaneously&nbsp;high in both groups and doesn9t correlate directly with HIV-infection presence. HHV and TB coinfection may cause poor disease prognosis.