Synthesis and Evaluation of Quinolino-Benzoxaboroles as Potential Antimicrobial Agents
Greeshma P. Kumpati, Michael Williams, Srinidhi Mereddy, Joseph L. Johnson, Shirisha Jonnalagadda
International Journal of Organic Chemistry · 2022-01
Abstract
Several quinolino-benzoxaborole derivatives have been prepared to start from aminobenzoxaboroles. These derivatives have been evaluated for their anti-cancer activity on human and murine cancer cell lines and based on their relative non-toxicity, these compounds were further evaluated for their antibacterial activity against E. coli, B. subtilis, and M. smegmatis. The synthesized compounds were also evaluated for antifungal activity in C. albicans and C. neoformans.
MeSH terms
- Antimicrobial
- Mycobacterium smegmatis
- Candida albicans
- Bacillus subtilis
- Chemistry
- Antifungal
- Antibacterial activity
- Stereochemistry
- Combinatorial chemistry