Mycobacterium tuberculosis Transcription Factor EmbR Regulates the Expression of Key Virulence Factors That Aid in <i>Ex Vivo</i> and <i>In Vivo</i> Survival
Suresh Kumar, Mehak Zahoor Khan, Neha Khandelwal, Chen Chongtham, Biplab Singha, Ankita Dabla, Debashree Behera, Archana Singh, et al. (12 authors)
mBio · 2022-04
Abstract
Mycobacterium tuberculosis modulates its transcriptional machinery in response to dynamic microenvironments encountered within the host. In this study, we identified that EmbR, a transcription factor, plays important roles in modulating cellular morphology, antibiotic resistance, and survival in the host.
MeSH terms
- Mycobacterium tuberculosis
- Ex vivo
- Virulence
- Transcription factor
- Virulence factor
- In vivo
- Tuberculosis
- Microbiology
- Biology
- Antibiotics
- Transcription (linguistics)
- Cell biology